eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats
Identifieur interne : 000261 ( Main/Exploration ); précédent : 000260; suivant : 000262eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats
Auteurs : Linya Guo [République populaire de Chine] ; Yanbing Li [République populaire de Chine] ; Ying Tian [République populaire de Chine] ; Shaoxin Gong [République populaire de Chine] ; Xi Chen [République populaire de Chine] ; Tianhong Peng [République populaire de Chine] ; Aiping Wang [République populaire de Chine] ; Zhisheng Jiang [République populaire de Chine]Source :
- Drug Design, Development and Therapy [ 1177-8881 ] ; 2019.
Abstract
Eukaryotic initiation factor 2α (eIF2α) plays important roles in the proliferation and survival of pulmonary artery smooth muscle cells (PASMCs) in animal hypoxia-induced pulmonary hypertension models. However, the underlying mechanism remains unknown at large. Autophagy has been reported to play a key role in the vascular remodeling in pulmonary arterial hypertension (PAH). The purposes of this study are to determine the functions of eIF2α and autophagy in the vascular remodeling of the monocrotaline-induced PAH rats and to clarify the correlation between eIF2α and autophagy.
We established a rat model of monocrotaline-induced PAH, and we established a cell model of platelet derived growth factor (PDGF)-induced PASMCs proliferation. The vascular morphology and the expression of eIF2α, LC3B, and p62 were assessed in the pulmonary arterial tissue of Sprague-Dawleyrats and PDGF-induced PASMCs.
Autophagy was significantly active in monocrotaline model group (MCT)-induced PAH rats, which obviously promotes vascular remodeling in MCT-induced PAH rats. Furthermore, the proliferation of PASMCs was induced by PDGF in vitro. The expression of LC3B, eIF2α was increased in the PDGF-induced PASMCs proliferation, and the expression of p62 was reduced in the PDGF-induced PASMCs proliferation. Moreover, eIF2α siRNA downregulated the expression of eIF2α and LC3B, and upregulated the expression of p62 in PDGF-induced PASMCs proliferation. eIF2α siRNA inhibited the PDGF-induced PASMCs proliferation. Finally, chloroquine can upregulate the protein expression of LC3B and p62, it also can inhibit proliferation in PDGF-induced PASMCs.
Based on these observations, we conclude that eIF2α promotes the proliferation of PASMCs and vascular remodeling in monocrotaline-induced PAH rats through accelerating autophagy pathway.
Url:
DOI: 10.2147/DDDT.S213817
PubMed: 31496656
PubMed Central: 6698179
Affiliations:
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Tianhong" sort="Peng, Tianhong" uniqKey="Peng T" first="Tianhong" last="Peng">Tianhong Peng</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Clinical Anatomy & Reproductive Medicine Application Institute, School of Medicine, University of South China</institution>,<addr-line>Hengyang</addr-line><addr-line>421001</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Aiping" sort="Wang, Aiping" uniqKey="Wang A" first="Aiping" last="Wang">Aiping Wang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Clinical Anatomy & Reproductive Medicine Application Institute, School of Medicine, University of South China</institution>,<addr-line>Hengyang</addr-line><addr-line>421001</addr-line>,<country>People’s Republic of China</country></nlm:aff><country 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strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Yanbing" sort="Li, Yanbing" uniqKey="Li Y" first="Yanbing" last="Li">Yanbing Li</name><affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>National Key Discipline of Human Anatomy, Southern Medical University</institution>,<addr-line>Guangzhou</addr-line><addr-line>510000</addr-line>,<addr-line>Guangdong</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0003"><institution>Guangdong Engineering Research Center for Translation of Medical 3D Printing Application</institution>,<addr-line>Guangzhou</addr-line>,<addr-line>510000</addr-line>,<addr-line>Guangdong</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tian, Ying" sort="Tian, Ying" uniqKey="Tian Y" first="Ying" last="Tian">Ying Tian</name><affiliation wicri:level="1"><nlm:aff id="AFF0004"><institution>Institute of Clinical Research, Affiliated Nanhua Hospital, University of South China</institution>,<addr-line>Hengyang</addr-line><addr-line>421002</addr-line>,<addr-line>Hunan</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0005"><institution>Postdoctoral Research Institute on Basic Medicine, University of South China</institution>,<addr-line>Hengyang</addr-line>,<addr-line>421001</addr-line>,<addr-line>Hunan</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gong, Shaoxin" sort="Gong, Shaoxin" uniqKey="Gong S" first="Shaoxin" last="Gong">Shaoxin Gong</name><affiliation wicri:level="1"><nlm:aff id="AFF0006"><institution>Department of Pathology, First Affiliated Hospital, University of South China</institution>,<addr-line>Hengyang</addr-line><addr-line>421001</addr-line>,<addr-line>Hunan</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Xi" sort="Chen, Xi" uniqKey="Chen X" first="Xi" last="Chen">Xi Chen</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Clinical Anatomy & Reproductive Medicine Application Institute, School of Medicine, University of South China</institution>,<addr-line>Hengyang</addr-line><addr-line>421001</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peng, Tianhong" sort="Peng, Tianhong" uniqKey="Peng T" first="Tianhong" last="Peng">Tianhong Peng</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Clinical Anatomy & Reproductive Medicine Application Institute, School of Medicine, University of South China</institution>,<addr-line>Hengyang</addr-line><addr-line>421001</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Aiping" sort="Wang, Aiping" uniqKey="Wang A" first="Aiping" last="Wang">Aiping Wang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Clinical Anatomy & Reproductive Medicine Application Institute, School of Medicine, University of South China</institution>,<addr-line>Hengyang</addr-line><addr-line>421001</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0004"><institution>Institute of Clinical Research, Affiliated Nanhua Hospital, University of South China</institution>,<addr-line>Hengyang</addr-line><addr-line>421002</addr-line>,<addr-line>Hunan</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0005"><institution>Postdoctoral Research Institute on Basic Medicine, University of South China</institution>,<addr-line>Hengyang</addr-line>,<addr-line>421001</addr-line>,<addr-line>Hunan</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0007"><institution>Key Laboratory for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, University of South China</institution>,<addr-line>Hengyang</addr-line><addr-line>421001</addr-line>,<addr-line>Hunan</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Zhisheng" sort="Jiang, Zhisheng" uniqKey="Jiang Z" first="Zhisheng" last="Jiang">Zhisheng Jiang</name><affiliation wicri:level="1"><nlm:aff id="AFF0007"><institution>Key Laboratory for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, University of South China</institution>,<addr-line>Hengyang</addr-line><addr-line>421001</addr-line>,<addr-line>Hunan</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Drug Design, Development and Therapy</title><idno type="eISSN">1177-8881</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S2001"><title>Purpose</title><p>Eukaryotic initiation factor 2α (eIF2α) plays important roles in the proliferation and survival of pulmonary artery smooth muscle cells (PASMCs) in animal hypoxia-induced pulmonary hypertension models. However, the underlying mechanism remains unknown at large. Autophagy has been reported to play a key role in the vascular remodeling in pulmonary arterial hypertension (PAH). The purposes of this study are to determine the functions of eIF2α and autophagy in the vascular remodeling of the monocrotaline-induced PAH rats and to clarify the correlation between eIF2α and autophagy.</p></sec><sec id="S2002"><title>Methods</title><p>We established a rat model of monocrotaline-induced PAH, and we established a cell model of platelet derived growth factor (PDGF)-induced PASMCs proliferation. The vascular morphology and the expression of eIF2α, LC3B, and p62 were assessed in the pulmonary arterial tissue of Sprague-Dawleyrats and PDGF-induced PASMCs.</p></sec><sec id="S2003"><title>Results</title><p>Autophagy was significantly active in monocrotaline model group (MCT)-induced PAH rats, which obviously promotes vascular remodeling in MCT-induced PAH rats. Furthermore, the proliferation of PASMCs was induced by PDGF in vitro. The expression of LC3B, eIF2α was increased in the PDGF-induced PASMCs proliferation, and the expression of p62 was reduced in the PDGF-induced PASMCs proliferation. Moreover, eIF2α siRNA downregulated the expression of eIF2α and LC3B, and upregulated the expression of p62 in PDGF-induced PASMCs proliferation. eIF2α siRNA inhibited the PDGF-induced PASMCs proliferation. Finally, chloroquine can upregulate the protein expression of LC3B and p62, it also can inhibit proliferation in PDGF-induced PASMCs.</p></sec><sec id="S2004"><title>Conclusion</title><p>Based on these observations, we conclude that eIF2α promotes the proliferation of PASMCs and vascular remodeling in monocrotaline-induced PAH rats through accelerating autophagy pathway.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Guo, Linya" sort="Guo, Linya" uniqKey="Guo L" first="Linya" last="Guo">Linya Guo</name></noRegion><name sortKey="Chen, Xi" sort="Chen, Xi" uniqKey="Chen X" first="Xi" last="Chen">Xi Chen</name><name sortKey="Gong, Shaoxin" sort="Gong, Shaoxin" uniqKey="Gong S" first="Shaoxin" last="Gong">Shaoxin Gong</name><name sortKey="Jiang, Zhisheng" sort="Jiang, Zhisheng" uniqKey="Jiang Z" first="Zhisheng" last="Jiang">Zhisheng Jiang</name><name sortKey="Li, Yanbing" sort="Li, Yanbing" uniqKey="Li Y" first="Yanbing" last="Li">Yanbing Li</name><name sortKey="Li, Yanbing" sort="Li, Yanbing" uniqKey="Li Y" first="Yanbing" last="Li">Yanbing Li</name><name sortKey="Peng, Tianhong" sort="Peng, Tianhong" uniqKey="Peng T" first="Tianhong" last="Peng">Tianhong Peng</name><name sortKey="Tian, Ying" sort="Tian, Ying" uniqKey="Tian Y" first="Ying" last="Tian">Ying Tian</name><name sortKey="Tian, Ying" sort="Tian, Ying" uniqKey="Tian Y" first="Ying" last="Tian">Ying Tian</name><name sortKey="Wang, Aiping" sort="Wang, Aiping" uniqKey="Wang A" first="Aiping" last="Wang">Aiping Wang</name><name sortKey="Wang, Aiping" sort="Wang, Aiping" uniqKey="Wang A" first="Aiping" last="Wang">Aiping Wang</name><name sortKey="Wang, Aiping" sort="Wang, Aiping" uniqKey="Wang A" first="Aiping" last="Wang">Aiping Wang</name><name sortKey="Wang, Aiping" sort="Wang, Aiping" uniqKey="Wang A" first="Aiping" last="Wang">Aiping Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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